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Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease

  • https://koreascience.kr/search.page?keywords=moringa
  • Abdull Razis, Ahmad Faizal (Food Safety Research Centre (FOSREC), Faculty of Food Science and Technology, Universiti Putra Malaysia)
  • Ibrahim, Muhammad Din  (Laboratory of UPM-MAKNA Cancer Research, Institute of Bioscience, Universiti Putra Malaysia)
  • Kntayya, Saie Brindha  (Laboratory of UPM-MAKNA Cancer Research, Institute of Bioscience, Universiti Putra Malaysia)
  • https://koreascience.kr/article/JAKO201435648479194.page
  • Moringa Cited Sources

  • Mbikay, M. (2012). Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: a review. Frontiers in Pharmacology, 3, 24. [2][25]
  • Vergara-Jimenez, M., Almatrafi, M. M., & Fernandez, M. L. (2017). Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants, 6(4), 91. [1][9][14]
  • Bosch, C. H. (2004). Moringa oleifera Lam. Record from Protabase. PROTA (Plant Resources of Tropical Africa/Ressources végétales de l’Afrique tropicale), Wageningen, Netherlands. [10][21]
  • Stohs, S. J., & Hartman, M. J. (2015). Review of the safety and efficacy of Moringa oleifera. Phytotherapy Research, 29(6), 796-804. [1][2][10][22]
  • Mehta, K., Balaraman, R., Amin, A. H., Bafna, P. A., & Gulati, O. D. (2003). Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits. Journal of Ethnopharmacology, 86(2-3), 191-195. [5][11][19]
  • Teixeira, E. M., Carvalho, M. R., Neves, V. A., Silva, M. A., & Arantes-Pereira, L. (2014). Chemical characteristics and fractionation of proteins from Moringa oleifera Lam. leaves. Food Chemistry, 147, 51-54. [13][15][16][17]
  • Chumark, P., Khunawat, P., Sanvarinda, Y., Phornchirasilp, S., Morales, N. P., Phivthongngam, L., … & Klai-upsorn, S. P. (2008). The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. Journal of Ethnopharmacology, 116(3), 439-446. [5][9][11][19]
  • Jaiswal, D., Rai, P. K., Kumar, A., Mehta, S., & Watal, G. (2009). Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. Journal of Ethnopharmacology, 123(3), 392-396. [2][25]
  • Ndong, M., Uehara, M., Katsumata, S. I., & Suzuki, K. (2007). Effects of oral administration of Moringa oleifera Lam on glucose tolerance in Goto-Kakizaki and wistar rats. Journal of Clinical Biochemistry and Nutrition, 40(3), 229-233. [2][25]
  • Sreelatha, S., & Padma, P. R. (2009). Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity. Plant foods for human nutrition, 64(4), 303-311. [9][14][18]
  • Amaglo, N. K., Bennett, R. N., Lo Curto, R. B., Rosa, E. A., Lo Turco, V., Giuffrida, A., … & Timpo, G. M. (2010). Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera L., grown in Ghana. Food Chemistry, 122(4), 1047-1054. [13][15][16][17][26]
  • Charoensin, S. (2014). Antioxidant and anticancer activities of Moringa oleifera leaves. Journal of Medicinal Plants Research, 8(7), 318-325. [9][14]
  • Aja, P. M., Nwachukwu, N., Ibiam, U. A., Igawa, S., & Orji, O. U. (2013). Chemical constituents of Moringa oleifera leaves and seeds from Abakaliki, Nigeria. American Journal of Phytomedicine and Clinical Therapeutics, 1(8), 748-759. [13][15][16][17]
  • Fahey, J. W. (2005). Moringa oleifera: a review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees for Life Journal, 1(5), 1-15. [1][3][10][21][22]
  • Gopalakrishnan, L., Doriya, K., & Kumar, D. S. (2016). Moringa oleifera: A review on nutritive importance and its medicinal application. Food Science and Human Wellness, 5(2), 49-56. [1][3][10][13][15][16][17][21][22][26]
  • Fuglie, L. J. (1999). The Miracle Tree: Moringa oleifera: Natural Nutrition for the Tropics. Church World Service, Dakar. 68 pp.; revised in 2001 and published as The Miracle Tree: The Multiple Attributes of Moringa, 172 pp. [1][3][10][21][22]
  • Thurber, M. D., & Fahey, J. W. (2009). Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the “Diffusion of Innovations” theory. Ecology of Food and Nutrition, 48(3), 212-225. [1][3][10][21][22]
  • Rockwood, J. L., Anderson, B. G., & Casamatta, D. A. (2013). Potential uses of Moringa oleifera and an examination of antibiotic efficacy conferred by M. oleifera seed and leaf extracts using crude extraction techniques available to underserved indigenous populations. International Journal of Phytotherapy Research, 3(2), 61-71. [7][14][23][24]
  • Daba, M. (2016). Miracle tree: A review on multi-purposes of Moringa oleifera and its implication for climate change mitigation. Journal of Earth Science & Climatic Change, 7(8). [1][3][10][21][22]
  • Luqman, S., Srivastava, S., Kumar, R., Maurya, A. K., & Chanda, D. (2012). Experimental assessment of Moringa oleifera leaf and fruit for its antistress, antioxidant, and scavenging potential using in vitro and in vivo assays. Evidence-Based Complementary and Alternative Medicine, 2012. [9][14][18]
  • Saini, R. K., Sivanesan, I., & Keum, Y. S. (2016). Phytochemicals of Moringa oleifera: a review of their nutritional, therapeutic and industrial significance. 3 Biotech, 6(2), 203. [13][15][16][17]
  • Olson, M. E., & Fahey, J. W. (2011). Moringa oleifera: a multi-purpose tree with potential for improvement of life and environment. AGROFORESTRY NEWS, 19(2), 9-10. [1][3][10][21][22]
  • Razis, A. F., Ibrahim, M. D., & Kntayya, S. B. (2014). Health benefits of Moringa oleifera. Asian Pacific Journal of Cancer Prevention, 15(20), 8571-8576. [1][9][14][22]
  • Nambiar, V. S., Guin, P., Parnami, S., & Daniel, M. (2010). Impact of antioxidants from drumstick leaves on the lipid profile of hyperlipidemics. Journal of Herbal Medicine and Toxicology, 4(1), 165-172. [5][11][19]
  • Nouman, W., Siddiqui, M. T., Basra, S. M., Farooq, H., Zubair, M., & Gull, T. (2013). Biomass production and nutritional quality of Moringa oleifera as a field crop. Turkish Journal of Agriculture and Forestry, 37(4), 410-419. [13][15][16][17][26]
  • Anwar, F., Latif, S., Ashraf, M., & Gilani, A. H. (2007). Moringa oleifera: a food plant with multiple medicinal uses. Phytotherapy research, 21(1), 17-25. [1][3][10][13][15][16][17][21][22][26]
  • Ruckmani, K., Kavimani, S., Anandan, R., & Jaykar, B. (1998). Effect of Moringa oleifera Lam on paracetamol-induced hepatoxicity. Indian journal of pharmaceutical sciences, 60(1), 33. [1][10]
  • Kumar, N. A., & Pari, L. (2003). Antioxidant action of Moringa oleifera Lam.(drumstick) against antitubercular drugs induced lipid peroxidation in rats. Journal of Medicinal Food, 6(3), 255-259. [1][10]
  • Kasolo, J. N., Bimenya, G. S., Ojok, L., Ochieng, J., & Ogwal-Okeng, J. W. (2010). Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities. Journal of Medicinal Plants Research, 4(9), 753-757. [13][15][16][17]
  • Chumark, P., Khunawat, P., Sanvarinda, Y., Phornchirasilp, S., Morales, N. P., Phivthongngam, L., … & Klai-upsorn, S. P. (2008). The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. Journal of Ethnopharmacology, 116(3), 439-446. [5][9][11][19]
  • Nair, A. G. R., & Subramanian, S. S. (1962). Chemical examination of the seeds of Moringa pterygosperma. Journal of Pharmaceutical Sciences, 51(6), 579-581. [13][15][16][17]
  • Leone, A., Spada, A., Battezzati, A., Schiraldi, A., Aristil, J., & Bertoli, S. (2015). Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves: an overview. International journal of molecular sciences, 16(6), 12791-12835. [1][3][10][13][15][16][17][21][22][26]
  • Brunelli, D., Tavecchio, M., Falcioni, C., Frapolli, R., Erba, E., Iori, R., … & D’Incalci, M. (2010). The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth and inflammatory changes. Anticancer Drugs, 21(8), 766-775. [9][14][23]
  • Sreelatha, S., Jeyachitra, A., & Padma, P. R. (2011). Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. Food and Chemical Toxicology, 49(6), 1270-1275. [9][14]
  • Pari, L., & Kumar, N. A. (2002). Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. Journal of Medicinal Food, 5(3), 171-177. [1][10]
  • Saini, R. K., Manoj, P., Shetty, N. P., Srinivasan, K., & Giridhar, P. (2016). Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats. Nutrition Research, 36(1), 46-55. [13][15][16][17][26]
  • Saini, R. K., Shetty, N. P., Prakash, M., & Giridhar, P. (2014). Effect of dehydration methods on retention of carotenoids, tocopherols, ascorbic acid and antioxidant activity in Moringa oleifera leaves and preparation of a RTE product. Journal of food science and technology, 51(9), 2176-2182. [13][15][16][17][26]
  • Gella, N., Malaisse, W. J., Platel, A., Braekman, J. C., & Daloze, D. (1993). In vitro effects of two novel anti-inflammatory steroids on rat pancreatic islet function. Biochemical Pharmacology, 46(9), 1615-1619. [23][24]
  • Brilhante, R. S., Sales, J. A., Pereira, V. S., Castelo-Branco, D. S., Cordeiro, R. A., de Souza Sampaio, C. M., … & Rocha, M. F. (2017). Research advances on the multiple uses of Moringa oleifera: A sustainable crop for different applications. Industrial Crops and Products, 106, 34-48. [1][3][10][13][15][16][17][21][22][26]
  • Donkor, A. M., Glover, R. L., Addae, D., & Kubi, K. A. (2013). Estimating the nutritional value of the leaves of Moringa oleifera on poultry. Food and Nutrition Sciences, 2013. [13][15][16][17][26]
  • Sánchez-Machado, D. I., Núñez-Gastélum, J. A., Reyes-Moreno, C., Ramírez-Wong, B., & López-Cervantes, J. (2010). Nutritional quality of edible parts of Moringa oleifera. Food Analytical Methods, 3(3), 175-180. [13][15][16][17][26]
https://doi.org/10.3390/ijms9030355

  • Natural Compounds for Cancer Treatment and Prevention

  • https://www.sciencedirect.com/science/article/abs/pii/S0278691517304714

  • The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones

    Mirielle C. Nauman, Jeremy J. Johnson

    Pharmacol Res. Author manuscript; available in PMC 2023 Jan 1.

    Published in final edited form as: Pharmacol Res. 2022 Jan; 175: 106032. Published online 2021 Dec 9. doi: 10.1016/j.phrs.2021.106032

    PMCID:

    PMC9597473

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    Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells

    Restituto Tocmo, Bryan Le, Amber Heun, Jan Peter Pijkeren, Kirk Parkin, Jeremy James Johnson

    Free Radic Biol Med. Author manuscript; available in PMC 2022 Feb 1.

    Published in final edited form as: Free Radic Biol Med. 2021 Feb 1; 163: 102–115. Published online 2020 Dec 9. doi: 10.1016/j.freeradbiomed.2020.11.018

    PMCID:

    PMC8647718

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    Non-Destructive Chemical Analysis of a Garcinia mangostana L. (Mangosteen) Herbarium Voucher Specimen

    Diana Kao, Joshua M. Henkin, Djaja Djendoel Soejarto, A. Douglas Kinghorn, Nicholas H. Oberlies

    Phytochem Lett. Author manuscript; available in PMC 2019 Dec 1.

    Published in final edited form as: Phytochem Lett. 2018 Dec; 28: 124–129. Published online 2018 Oct 12. doi: 10.1016/j.phytol.2018.10.001

    PMCID:

    PMC6317376

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    Inhibition of CDK2/CyclinE1 by xanthones from the mangosteen (Garcinia mangostana): A structure-activity relationship study

    Mirielle C. Nauman, Restituto Tocmo, Bhaskar Vemu, Jacob P. Veenstra, Jeremy J. Johnson

    Nat Prod Res. Author manuscript; available in PMC 2021 Dec 1.

    Published in final edited form as: Nat Prod Res. 2021 Dec; 35(23): 5429–5433. Published online 2020 Jul 21. doi: 10.1080/14786419.2020.1777413

    PMCID:

    PMC7854934

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    Select item 32379085.

    Xanthones from Mangosteen Extracts as Natural Chemopreventive Agents: Potential Anticancer Drugs

    1. Shan, Q. Ma, K. Guo, J. Liu, W. Li, F. Wang, E. Wu

    Curr Mol Med. Author manuscript; available in PMC 2011 Dec 15.

    Published in final edited form as: Curr Mol Med. 2011 Dec 1; 11(8): 666–677. doi: 10.2174/156652411797536679

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    PMC3237908

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    Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer

    Gongbo Li, Stacey Thomas, Jeremy J. Johnson

    Front Pharmacol. 2013; 4: 80. Published online 2013 Jun 26. doi: 10.3389/fphar.2013.00080

    PMCID:

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    Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement

    Young-Won Chin, A. Douglas Kinghorn

    Mini Rev Org Chem. Author manuscript; available in PMC 2011 May 9.

    Published in final edited form as: Mini Rev Org Chem. 2008 Nov 1; 5(4): 355–364. doi: 10.2174/157019308786242223

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    PMC3090081

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    Pharmacokinetic characterization of mangosteen (Garcinia mangostana) fruit extract standardized to α-mangostin in C57BL/6 mice

    Sakina M. Petiwala, Gongbo Li, Atulkumar Ramaiya, Anoop Kumar, Ravinder K. Gill, Seema Saksena, Jeremy J. Johnson

    Nutr Res. Author manuscript; available in PMC 2018 Dec 18.

    Published in final edited form as: Nutr Res. 2014 Apr; 34(4): 336–345. Published online 2014 Mar 12. doi: 10.1016/j.nutres.2014.03.002

    PMCID:

    PMC6298434

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    Structure activity relationship of xanthones for inhibition of Cyclin Dependent Kinase 4 from mangosteen (Garcinia mangostana L.)

    Bhaskar Vemu, Mirielle C. Nauman, Jacob P. Veenstra, Jeremy J. Johnson

    Int J Nutr. Author manuscript; available in PMC 2019 Jul 30.

    Published in final edited form as: Int J Nutr. 2019; 4(2): 38–45. Published online 2019 Jun 16.

    PMCID:

    PMC6667231

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    The effect of gartanin, a naturally- occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis and the growth of human urinary bladder cancer cell Lines

    Zhongbo Liu, Mitchell Antalek, Linda Nguyen, Xuesen Li, Xuejiao Tian, Amy Le, Xiaolin Zi

    Nutr Cancer. Author manuscript; available in PMC 2014 Jan 1.

    Published in final edited form as: Nutr Cancer. 2013; 65(0 1): 68–77. doi: 10.1080/01635581.2013.785011

    PMCID:

    PMC3671488

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    α-Mangostin: A Dietary Antioxidant Derived from the Pericarp of Garcinia mangostana L. Inhibits Pancreatic Tumor Growth in Xenograft Mouse Model

    Bilal Bin Hafeez, Ala Mustafa, Joseph W. Fischer, Ashok Singh, Weixiong Zhong, Mohammed Ozair Shekhani, Louise Meske, Thomas Havighurst, KyungMann Kim, Ajit Kumar Verma

    Antioxid Redox Signal. 2014 Aug 10; 21(5): 682–699. doi: 10.1089/ars.2013.5212

    PMCID:

    PMC4104617

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    Cytotoxic Xanthone Constituents of the Stem Bark of Garcinia mangostana (Mangosteen)

    Ah-Reum Han, Jeong-Ah Kim, Daniel D. Lantvit, Leonardus B.S. Kardono, Soedarsono Riswan, Heebyung Chai, Esperanza J. Carcache de Blanco, Norman R. Farnsworth, Steven M. Swanson, A. Douglas Kinghorn

    J Nat Prod. Author manuscript; available in PMC 2010 Nov 1.

    Published in final edited form as: J Nat Prod. 2009 Nov; 72(11): 2028–2031. doi: 10.1021/np900517h

    PMCID:

    PMC2887388

    AbstractArticlePDF–535K

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    Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase

    MyPhuong T. Le, Miguel A. Lanaspa, Christina M. Cicerchi, Jatinder Rana, Jeffrey D. Scholten, Brandi L. Hunter, Christopher J. Rivard, R. Keith Randolph, Richard J. Johnson

    PLoS One. 2016; 11(6): e0157458. Published online 2016 Jun 20. doi: 10.1371/journal.pone.0157458

    PMCID:

    PMC4913896

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    Current Status and Contemporary Approaches to the Discovery of Antitumor Agents from Higher Plants

    Garima Agarwal, Peter J. Blanco Carcache, Ermias Mekuria Addo, A. Douglas Kinghorn

    Biotechnol Adv. Author manuscript; available in PMC 2020 Jul 8.

    Published before final editing as: Biotechnol Adv. 2019 Jan 8 : S0734-9750(19)30004-7. doi: 10.1016/j.biotechadv.2019.01.004 [Epub ahead of print]

    PMCID:

    PMC6614024

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    Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter

    Chung-Pu Wu, Sung-Han Hsiao, Megumi Murakami, Yu-Jen Lu, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh. V. Ambudkar, Yu-Shan Wu

    Mol Pharm. Author manuscript; available in PMC 2021 Jan 25.

    Published in final edited form as: Mol Pharm. 2017 Aug 7; 14(8): 2805–2814. Published online 2017 Jul 5. doi: 10.1021/acs.molpharmaceut.7b00334

    PMCID:

    PMC7830752

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    Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin

    Kanjana Jittiporn, Jutamas Suwanpradid, Chintan Patel, Modesto Rojas, Suwan Thirawarapan, Primchanien Moongkarndi, Wisuda Suvitayavat, Ruth B. Caldwell

    Microvasc Res. Author manuscript; available in PMC 2015 May 1.

    Published in final edited form as: Microvasc Res. 2014 May; 93: 72–79. Published online 2014 Apr 8. doi: 10.1016/j.mvr.2014.03.005

    PMCID:

    PMC4075264

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    Select item 386731717.

    Selective Modulation of Endoplasmic Reticulum Stress Markers in Prostate Cancer Cells by a Standardized Mangosteen Fruit Extract

    Gongbo Li, Sakina M. Petiwala, Dana R. Pierce, Larisa Nonn, Jeremy J. Johnson

    PLoS One. 2013; 8(12): e81572. Published online 2013 Dec 18. doi: 10.1371/journal.pone.0081572

    PMCID:

    PMC3867317

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    Xanthones from the Botanical Dietary Supplement Mangosteen (Garcinia mangostana) with Aromatase Inhibitory Activity

    Marcy J. Balunas, Bin Su, Robert W. Brueggemeier, A. Douglas Kinghorn

    J Nat Prod. Author manuscript; available in PMC 2008 Oct 24.

    Published in final edited form as: J Nat Prod. 2008 Jul; 71(7): 1161–1166. Published online 2008 Jun 18. doi: 10.1021/np8000255

    PMCID:

    PMC2572570

    AbstractArticlePDF–704K

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    Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

    1. Annécie Benatrehina, Li Pan, C. Benjamin Naman, Jie Li, A. Douglas Kinghorn

    J Tradit Complement Med. 2018 Apr; 8(2): 267–277. Published online 2018 Mar 2. doi: 10.1016/j.jtcme.2018.01.006

    PMCID:

    PMC5934707

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    Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone

    Balaji Krishnamachary, Dharmalingam Subramaniam, Prasad Dandawate, Sivapriya Ponnurangam, Pugazhendhi Srinivasan, Prabhu Ramamoorthy, Shahid Umar, Sufi Mary Thomas, Animesh Dhar, Seth Septer, Scott J. Weir, Thomas Attard, Shrikant Anant

    Oncotarget. 2019 Sep 24; 10(54): 5576–5591. Published online 2019 Sep 24. doi: 10.18632/oncotarget.27159

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    Select item 314415021.

    Chemistry and Biology of the Caged Garcinia Xanthones

    Oraphin Chantarasriwong, Dr. Ayse Batova, Dr. Warinthorn Chavasiri, Dr. Emmanuel A. Theodorakis

    Chemistry. Author manuscript; available in PMC 2011 Sep 3.

    Published in final edited form as: Chemistry. 2010 Sep 3; 16(33): 9944–9962. doi: 10.1002/chem.201000741

    PMCID:

    PMC3144150

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    Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice

    Fabiola Gutierrez-Orozco, Jennifer M. Thomas-Ahner, Lisa D. Berman-Booty, Jeffrey D. Galley, Chureeporn Chitchumroonchokchai, Thomas Mace, Sunit Suksamrarn, Michael T. Bailey, Steven K. Clinton, Gregory B. Lesinski, Mark L. Failla

    Mol Nutr Food Res. Author manuscript; available in PMC 2015 Jun 1.

    Published in final edited form as: Mol Nutr Food Res. 2014 Jun; 58(6): 1226–1238. Published online 2014 Feb 17. doi: 10.1002/mnfr.201300771

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    PMC4076011

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    Formation and biological targets of botanical o-quinones

    Judy L. Bolton, Tareisha L. Dunlap, Birgit M Dietz

    Food Chem Toxicol. Author manuscript; available in PMC 2019 Jul 22.

    Published in final edited form as: Food Chem Toxicol. 2018 Oct; 120: 700–707. Published online 2018 Jul 29. doi: 10.1016/j.fct.2018.07.050

    PMCID:

    PMC6643002

    AbstractArticlePDF–663K

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    α-Mangostin Disrupts the Development of Streptococcus mutans Biofilms and Facilitates Its Mechanical Removal

    Phuong Thi Mai Nguyen, Megan L. Falsetta, Geelsu Hwang, Mireya Gonzalez-Begne, Hyun Koo

    PLoS One. 2014; 9(10): e111312. Published online 2014 Oct 28. doi: 10.1371/journal.pone.0111312

    PMCID:

    PMC4211880

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    Select item 327127125.

    α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth

    Jeremy J. Johnson, Sakina M. Petiwala, Deeba N. Syed, John T. Rasmussen, Vaqar M. Adhami, Imtiaz A. Siddiqui, Amanda M. Kohl, Hasan Mukhtar

    Carcinogenesis. 2012 Feb; 33(2): 413–419. Published online 2011 Dec 9. doi: 10.1093/carcin/bgr291

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    PMC3271271

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    Select item 694686226.

    Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression and autophagy

    Victor Pham, Raymond Rendon, Vinh X Le, Matthew Tippin, Dong-Jun Fu, Thanh H Le, Marvin Miller, Ericka Agredano, Jose Cedano, Xiaolin Zi

    Mol Carcinog. Author manuscript; available in PMC 2021 Feb 1.

    Published in final edited form as: Mol Carcinog. 2020 Feb; 59(2): 193–201. Published online 2019 Nov 29. doi: 10.1002/mc.23140

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    PMC6946862

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    DOXORUBICIN-INDUCED CENTRAL NERVOUS SYSTEM TOXICITY AND PROTECTION BY XANTHONE DERIVATIVE OF GARCINIA MANGOSTANA

    1. Tangpong, S. Miriyala, T. Noel, C. Sinthupibulyakit, P. Jungsuwadee, D. K. St. Clair

    Neuroscience. Author manuscript; available in PMC 2012 Feb 23.

    Published in final edited form as: Neuroscience. 2011 Feb 23; 175: 292–299. Published online 2010 Nov 11. doi: 10.1016/j.neuroscience.2010.11.007

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    Adipocyte reporter assays: Application for identification of anti-inflammatory and antioxidant properties of mangostin xanthones

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    α-Mangostin: Anti-Inflammatory Activity and Metabolism by Human Cells

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    Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites

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    The Biological Activity of α-Mangostin, a Larvicidal Botanic Mosquito Sterol Carrier Protein-2 Inhibitor

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    In Vitro and In Vivo Bactericidal and Antibiofilm Efficacy of Alpha Mangostin Against Staphylococcus aureus Persister Cells

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    The traditional anti-diarrheal remedy, Garcinia buchananii stem bark extract, inhibits propulsive motility and fast synaptic potentials in the guinea pig distal colon

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    Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin

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    A Virtual Screening Approach For Identifying Plants with Anti H5N1 Neuraminidase Activity

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    Natural Products as Aromatase Inhibitors

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    Potential Anticancer Agents Characterized from Selected Tropical Plants

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    Xanthones in Mangosteen Juice Are Absorbed and Partially Conjugated by Healthy Adults

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    An antiproliferative xanthone of Symphonia pauciflora from the Madagascar rainforest

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    Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450

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    The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs

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    Knowledge and perceptions about diet and physical activity among Sri Lankan adults with diabetes mellitus: a qualitative study

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    Intrinsic Therapeutic Applications of Noble Metal Nanoparticles: Past, Present and Future

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    Operational definition of complementary, alternative, and integrative medicine derived from a systematic search

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    22nd European Congress on Obesity (ECO2015), Prague, Czech Republic, May 6-9, 2015: Abstracts

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    Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia

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    Carnosol, a dietary diterpene from rosemary (Rosmarinus officinalis) activates Nrf2 leading to sestrin 2 induction in colon cells

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    Bioactivity and Metabolomics Profiling of Endophytic Actinobacteria Isolated from Roots of the Medicinal Plants Dominant in South Asian Region

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    Biodiversity of Convolvulaceous species that contain Ergot Alkaloids, Indole Diterpene Alkaloids, and Swainsonine

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    Riluzole induces AR degradation via endoplasmic reticulum stress pathway in androgen-dependent and castration-resistant prostate cancer cells

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    Bioassay-guided Isolation of Antioxidant and Cytoprotective Constituents from a Maqui Berry (Aristotelia chilensis) Dietary Supplement Ingredient as Markers for Qualitative and Quantitative Analysis

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    Targeting metabolic reprogramming by influenza infection for therapeutic intervention

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    Antiviral Effects of Blackberry Extract Against Herpes Simplex Virus Type 1

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    Targeting Truncated Retinoid X Receptor-α by CF31 induces TNFα-dependent apoptosis

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    Poly (l-lactic acid)-based modified nanofibrous membrane with dual drug release capability for GBR application

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    Biosynthesis of para-Cyclophane Containing Hirsutellone-Family of Fungal Natural Products

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    TUNEL Assay: A Powerful Tool for Kidney Injury Evaluation

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    Erythrocyte-Derived Nanoparticles with Folate Functionalization for Near Infrared Pulsed Laser-Mediated Photo-Chemotherapy of Tumors

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    In situ Treatment With Novel Microbiocide Inhibits Methicillin Resistant Staphylococcus aureus in a Murine Wound Infection Model

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    The Role of Chronic Inflammatory Bone and Joint Disorders in the Pathogenesis and Progression of Alzheimer’s Disease

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    Development of a human APOE knock-in mouse model for study of cognitive function after cancer chemotherapy

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    An update on lupus animal models

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    Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese

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    Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer

    Mohammed Sikander, Bilal Bin Hafeez, Shabnam Malik, Abdulrhman Alsayari, Fathi T. Halaweish, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi

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    Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone

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    Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities

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    Redox biology in normal cells and cancer: Restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment

    Mark Noble, Margot Mayer-Pröschel, Zaibo Li, Tiefei Dong, Wanchang Cui, Christoph Pröschel, Ibro Ambeskovic, Joerg Dietrich, Ruolan Han, Yin Miranda Yang, Christopher Folts, Jennifer Stripay, Hsing-Yu Chen, Brett M. Stevens

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    Comparison of explicit and incidental learning strategies in memory-impaired patients

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    A Comparative Evaluation of Tools to Predict Metabolite Profiles From Microbiome Sequencing Data

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    Gambogic Acid Inhibits STAT3 Phosphorylation Through Activation of Protein Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis

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    Review of the Breathability and Filtration Efficiency of Common Household Materials for Face Masks

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    Acute Hepatotoxicity After Ingestion of Morinda citrifolia (Noni Berry) Juice in a 14-year-old Boy

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    Neurohormetic Phytochemicals: An Evolutionary – Bioenergetic Perspective

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    Lupeol, A Novel Anti-inflammatory and Anti-cancer Dietary Triterpene

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    A Survey of the Protective Effects of Some Commercially available antioxidant supplements in genetic and chemically induced models of oxidative stress in Drosophila melanogaster

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    Anti-Diabetic Potential of Noni: The Yin and the Yang

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    Predicting metabolomic profiles from microbial composition through neural ordinary differential equations

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    Anti-Inflammatory Benefits of Food Ingredients in Periodontal Diseases

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    Pathogens. 2023 Apr; 12(4): 520. Published online 2023 Mar 27. doi: 10.3390/pathogens12040520

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    Expanding the E-Liquid Flavor Wheel: Classification of Emerging E-Liquid Flavors in Online Vape Shops

    Shaoying Ma, Zefeng Qiu, Qian Yang, John F. P. Bridges, Jian Chen, Ce Shang

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    Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy

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    Microbiome as an immune regulator in health, disease, and therapeutics

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    Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology

    Marcus J. G.W. Ladds, Gergana Popova, Andrés Pastor-Fernández, Srinivasaraghavan Kannan, Ingeborg M.M. van Leeuwen, Maria Håkansson, Björn Walse, Fredrik Tholander, Ravi Bhatia, Chandra S. Verma, David P. Lane, Sonia Laín

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    Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers

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    Integr Food Nutr Metab. Author manuscript; available in PMC 2019 May 2.

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    Preclinical investigation of pegylated arginase 1 as a treatment for retina and brain injury

    Abdelrahman Y Fouda, Wael Eldahshan, Zhimin Xu, Tahira Lemtalsi, Esraa Shosha, Syed Ah Zaidi, Ammar A Abdelrahman, Paul Ning-Man Cheng, S Priya Narayanan, R William Caldwell, Ruth B Caldwell

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    Pesticide use in Thailand: Current situation, health risks, and gaps in research and policy

    Wisanti Laohaudomchok, Noppanun Nankongnab, Somkiat Siriruttanapruk, Pakasinee Klaimala, Witoon Lianchamroon, Prokchol Ousap, Marut Jatiket, Puangrat Kajitvichyanukul, Noppadon Kitana, Wattasit Siriwong, Thiravat Hemachudhah, Jutamaad Satayavivad, Mark Robson, Lindsay Jaacks, Dana Boyd Barr, Pornpimol Kongtip, Susan Woskie

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    Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

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    Design of a “Mini” Nucleic Acid Probe for Cooperative Binding of an RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1

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    Natural Products and HIV/AIDS

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    AIDS Res Hum Retroviruses. 2018 Jan 1; 34(1): 31–38. Published online 2018 Jan 1. doi: 10.1089/aid.2017.0232

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    Compliance to dietary guidelines on fruit and vegetable intake and prevalence of hypertension among Vietnamese adults, 2015

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    Ormeloxifene suppresses prostate tumor growth and metastatic phenotypes via inhibition of oncogenic β-catenin signaling and EMT progression

    Bilal Bin Hafeez, Aditya Ganju, Mohammed Sikander, Vivek K. Kashyap, Zubair Bin Hafeez, Neeraj Chauhan, Shabnam Malik, Andrew E Massey, Manish K. Tripathi, Fathi T. Halaweish, Nadeem Zafar, Man M. Singh, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi

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    BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway

    Melissa M. Ledet, Robyn Anderson, Rebecca Harman, Aaron Muth, Paul R. Thompson, Scott A. Coonrod, Gerlinde R. Van de Walle

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    Bipolar disorder in youth is associated with increased levels of vitamin D-binding protein

    Brawnie Petrov, Ayat Aldoori, Cindy James, Kefeng Yang, Guillermo Perez Algorta, Aejin Lee, Liwen Zhang, Tao Lin, Reem Al Awadhi, Jonathan R. Parquette, Arpad Samogyi, L. Eugene Arnold, Mary A. Fristad, Barbara Gracious, Ouliana Ziouzenkova

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    The Ossabaw Pig Is a Suitable Translational Model to Evaluate Dietary Patterns and Coronary Artery Disease Risk

    Nirupa R Matthan, Gloria Solano-Aguilar, Huicui Meng, Stefania Lamon-Fava, Audrey Goldbaum, Maura E Walker, Saebyeol Jang, Sukla Lakshman, Aleksey Molokin, Yue Xie, Ethiopia Beshah, James Stanley, Joseph F Urban Jr., Alice H Lichtenstein

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    Commensal Fungi in Health and Disease

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    Cell Host Microbe. Author manuscript; available in PMC 2018 Aug 9.

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    Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway

    Zhongbo Liu, U-Syn Ha, Ke Yu, Chunli Wu, Noriko Yokoyama, Xiaolin Zi

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    Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention

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    Egg yolks inhibit activation of NF-κB and expression of its target genes in adipocytes after partial delipidation

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    J Agric Food Chem. Author manuscript; available in PMC 2015 Mar 17.

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    Centrifugal partition chromatography enables selective enrichment of trimeric and tetrameric proanthocyanidins for biomaterial development

    Rasika S Phansalkar, Joo-Won Nam, Shao-Nong Chen, James B. McAlpine, Ariene A Leme, Berdan Aydin, Ana-Karina Bedran-Russo, Guido F. Pauli

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    Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer

    Riley A. Hampsch, Kevin Shee, Darcy Bates, Lionel D. Lewis, Laurent Désiré, Bertrand Leblond, Eugene Demidenko, Kurtis Stefan, Yina H. Huang, Todd W. Miller

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    Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes

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    De Novo Emergence of Odor Category Representations in the Human Brain

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    Syntheses of (+)-30-epi-, (−)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations

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    The Public Health Impact of Herbs and Nutritional Supplements

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    Pharm Biol. Author manuscript; available in PMC 2010 Aug 1.

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    High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

    Jason Davenport, Maurie Balch, Lakshmi Galam, Antwan Girgis, Jessica Hall, Brian S. J. Blagg, Robert L. Matts

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    Probiotics in Clostridium difficile Infection

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    Using Crowdsourcing to Evaluate Published Scientific Literature: Methods and Example

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    Gene-Diet Interactions on Colorectal Cancer Risk

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    Immunity to Commensal Fungi: Detente and Disease

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